Advances in biopharma chromatography technology

New recombinant protein A affinity chromatography resin responds to the industry’s need for greater efficiency in monoclonal antibodies (mAbs) processing, helping to bring life-changing therapies to market faster.

Biopharma researcher in lab


Recombinant protein A affinity chromatography resin

Recombinant protein A affinity chromatography resin

PROchievA resins Producing breakthrough treatments requires continual advances in bioprocessing productivity. That’s why Avantor® is your trusted partner in executing life-saving therapies.

The J.T.Baker® BAKERBOND® PROchievA resin uses a novel, proprietary ligand to provide best-in-class purification in critical protein A chromatography step of mAbs manufacturing.

In performance tests conducted against comparable protein A resins, the BAKERBOND® PROchievA resin showed excellent dynamic binding capacity for mAbs and demonstrated improved purification results in Fc-Fusion proteins and other, emerging molecules.

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Novel Purification Technologies and Approaches to Maximize Speed, Efficiency and Process Optimization Jungmin Oh, Ph.D. Manager, New Product Development, Avantor On Demand Webinar


Improved supply chain security and performance

With the BAKERBOND® PROchievA resin, Avantor offers an independent chromatography resin supply alternative to other commercially-available purification products, providing greater supply chain flexibility and security along with best-in-class performance.

In several applications, the BAKERBOND® PROchievA resin was shown to deliver higher levels of protein purity post-protein A chromatography, thus reducing the burden on subsequent purification operations. These include several examples in the emerging market for Fc-Fusion proteins (Fig.1).

Fc-Fusion protein study comparison

A standard particle size and agarose base allows for higher flow, resulting in greater efficiency in downstream processing, without needing to change established column packaging procedures.

Trusted solutions for mAbs manufacturing

PROchievA resins Avantor’s J.T.Baker® brand process chromatography resins and cGMP chemicals allow biopharma manufacturers to realize higher production efficiencies, meet stringent regulatory requirements and accelerate regulatory approval in bringing new mAbs to market.

Learn more about the entire range of J.T.Baker® BAKERBOND® process chromatograpy resins, now available in convenient, pre-packaged lab column configurations.